Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3899298..3899955 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag PTC87_RS18535 Protein ID WP_021242050.1
Coordinates 3899298..3899708 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag PTC87_RS18540 Protein ID WP_010435322.1
Coordinates 3899689..3899955 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS18515 (PTC87_18515) 3895291..3897024 - 1734 WP_033146589.1 single-stranded-DNA-specific exonuclease RecJ -
PTC87_RS18520 (PTC87_18520) 3897030..3897743 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTC87_RS18525 (PTC87_18525) 3897772..3898668 - 897 WP_023309098.1 site-specific tyrosine recombinase XerD -
PTC87_RS18530 (PTC87_18530) 3898770..3899291 + 522 WP_023309099.1 flavodoxin FldB -
PTC87_RS18535 (PTC87_18535) 3899298..3899708 - 411 WP_021242050.1 protein YgfX Toxin
PTC87_RS18540 (PTC87_18540) 3899689..3899955 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
PTC87_RS18545 (PTC87_18545) 3900250..3901230 + 981 WP_033146590.1 tRNA-modifying protein YgfZ -
PTC87_RS18550 (PTC87_18550) 3901305..3901964 - 660 WP_033146591.1 hemolysin III family protein -
PTC87_RS18555 (PTC87_18555) 3902130..3902441 - 312 WP_033146592.1 N(4)-acetylcytidine aminohydrolase -
PTC87_RS18560 (PTC87_18560) 3902493..3903224 + 732 WP_029739204.1 MurR/RpiR family transcriptional regulator -
PTC87_RS18565 (PTC87_18565) 3903341..3904774 + 1434 WP_033146593.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T272173 WP_021242050.1 NZ_CP117723:c3899708-3899298 [Enterobacter asburiae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT272173 WP_010435322.1 NZ_CP117723:c3899955-3899689 [Enterobacter asburiae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References