Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2329655..2330181 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PTC87_RS11130 Protein ID WP_000323025.1
Coordinates 2329894..2330181 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PTC87_RS11125 Protein ID WP_000534858.1
Coordinates 2329655..2329894 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS11100 (PTC87_11100) 2324857..2326047 + 1191 WP_033145555.1 cytochrome c biogenesis protein/redoxin -
PTC87_RS11105 (PTC87_11105) 2326052..2326810 - 759 WP_033145556.1 trans-aconitate 2-methyltransferase -
PTC87_RS11110 (PTC87_11110) 2327013..2328353 + 1341 WP_004196353.1 IS1202-like element ISEsa1 family transposase -
PTC87_RS11115 (PTC87_11115) 2328790..2329122 - 333 WP_001317460.1 FlxA-like family protein -
PTC87_RS11120 (PTC87_11120) 2329325..2329630 - 306 WP_001326990.1 protein YdfV -
PTC87_RS11125 (PTC87_11125) 2329655..2329894 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PTC87_RS11130 (PTC87_11130) 2329894..2330181 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PTC87_RS11135 (PTC87_11135) 2330511..2331149 + 639 WP_033145557.1 acyl-homoserine-lactone synthase -
PTC87_RS11140 (PTC87_11140) 2331164..2331856 - 693 WP_033145558.1 LuxR family transcriptional regulator -
PTC87_RS11145 (PTC87_11145) 2332159..2332743 - 585 WP_033145559.1 NUDIX domain-containing protein -
PTC87_RS11150 (PTC87_11150) 2332830..2333597 + 768 WP_033145560.1 DeoR/GlpR family DNA-binding transcription regulator -
PTC87_RS11155 (PTC87_11155) 2333610..2333981 - 372 WP_033145561.1 VOC family protein -
PTC87_RS11160 (PTC87_11160) 2334069..2334497 - 429 WP_033145562.1 DUF4354 family protein -
PTC87_RS11165 (PTC87_11165) 2334534..2334977 - 444 WP_033145563.1 PACE efflux transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272164 WP_000323025.1 NZ_CP117723:2329894-2330181 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272164 WP_000534858.1 NZ_CP117723:2329655-2329894 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References