Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1721024..1721821 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag PTC87_RS08155 Protein ID WP_172421424.1
Coordinates 1721321..1721821 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag PTC87_RS08150 Protein ID WP_008499829.1
Coordinates 1721024..1721293 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS08120 (PTC87_08120) 1716651..1717094 - 444 WP_032658095.1 helix-turn-helix domain-containing protein -
PTC87_RS08125 (PTC87_08125) 1717247..1718488 + 1242 WP_033145159.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
PTC87_RS08130 (PTC87_08130) 1718522..1718749 - 228 WP_033145160.1 YccJ family protein -
PTC87_RS08135 (PTC87_08135) 1718770..1719366 - 597 WP_023311076.1 NAD(P)H:quinone oxidoreductase -
PTC87_RS08140 (PTC87_08140) 1719757..1719927 + 171 WP_023311077.1 general stress protein -
PTC87_RS08145 (PTC87_08145) 1720045..1720962 + 918 WP_033145161.1 DMT family transporter -
PTC87_RS08150 (PTC87_08150) 1721024..1721293 + 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
PTC87_RS08155 (PTC87_08155) 1721321..1721821 + 501 WP_172421424.1 GNAT family N-acetyltransferase Toxin
PTC87_RS08160 (PTC87_08160) 1721895..1723217 - 1323 WP_033145163.1 pyrimidine utilization transport protein G -
PTC87_RS08165 (PTC87_08165) 1723239..1723733 - 495 WP_032658088.1 pyrimidine utilization flavin reductase protein F -
PTC87_RS08170 (PTC87_08170) 1723743..1724333 - 591 WP_033145164.1 malonic semialdehyde reductase -
PTC87_RS08175 (PTC87_08175) 1724343..1725143 - 801 WP_033145165.1 pyrimidine utilization protein D -
PTC87_RS08180 (PTC87_08180) 1725151..1725537 - 387 WP_033145166.1 pyrimidine utilization protein C -
PTC87_RS08185 (PTC87_08185) 1725549..1726238 - 690 WP_033145167.1 pyrimidine utilization protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18969.67 Da        Isoelectric Point: 7.9145

>T272163 WP_172421424.1 NZ_CP117723:1721321-1721821 [Enterobacter asburiae]
MLSEGTDYDFEDFDCGEPSLNAFLAEHLVRQHNGRILRAYLLKERDRPRVLGYYTLSGSCFERAMLPSKTQQRRIPYINV
PSVTLGRLAVDKTLQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALNERAKRFYLKQGFIPLTAENSHSLFFPTKSIE
RLFEQE

Download         Length: 501 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT272163 WP_008499829.1 NZ_CP117723:1721024-1721293 [Enterobacter asburiae]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References