Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1054204..1054824 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag PTC87_RS04940 Protein ID WP_008499287.1
Coordinates 1054204..1054422 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag PTC87_RS04945 Protein ID WP_008499288.1
Coordinates 1054450..1054824 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS04910 (PTC87_04910) 1050218..1050478 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
PTC87_RS04915 (PTC87_04915) 1050481..1050621 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PTC87_RS04920 (PTC87_04920) 1050618..1051328 - 711 WP_033144788.1 GNAT family protein -
PTC87_RS04925 (PTC87_04925) 1051430..1052890 + 1461 WP_033144789.1 PLP-dependent aminotransferase family protein -
PTC87_RS04930 (PTC87_04930) 1052862..1053329 - 468 WP_023310598.1 YlaC family protein -
PTC87_RS04935 (PTC87_04935) 1053447..1053998 - 552 WP_033144790.1 maltose O-acetyltransferase -
PTC87_RS04940 (PTC87_04940) 1054204..1054422 - 219 WP_008499287.1 HHA domain-containing protein Toxin
PTC87_RS04945 (PTC87_04945) 1054450..1054824 - 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
PTC87_RS04950 (PTC87_04950) 1055336..1058482 - 3147 WP_029741964.1 multidrug efflux RND transporter permease subunit AcrB -
PTC87_RS04955 (PTC87_04955) 1058505..1059698 - 1194 WP_029741963.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T272162 WP_008499287.1 NZ_CP117723:c1054422-1054204 [Enterobacter asburiae]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT272162 WP_008499288.1 NZ_CP117723:c1054824-1054450 [Enterobacter asburiae]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References