Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 590668..591244 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name shpA Uniprot ID A0A4R0G892
Locus tag PTC87_RS02750 Protein ID WP_010427219.1
Coordinates 590668..590955 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A411GC49
Locus tag PTC87_RS02755 Protein ID WP_033144548.1
Coordinates 590942..591244 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS02725 (PTC87_02725) 585784..586479 + 696 WP_033144544.1 winged helix-turn-helix domain-containing protein -
PTC87_RS02730 (PTC87_02730) 586629..587099 + 471 WP_033144545.1 MarR family transcriptional regulator -
PTC87_RS02735 (PTC87_02735) 587096..588163 + 1068 WP_101744430.1 HlyD family secretion protein -
PTC87_RS02740 (PTC87_02740) 588153..589229 + 1077 WP_023310256.1 DUF2955 domain-containing protein -
PTC87_RS02745 (PTC87_02745) 589226..590497 - 1272 WP_033144547.1 DUF445 domain-containing protein -
PTC87_RS02750 (PTC87_02750) 590668..590955 + 288 WP_010427219.1 BrnT family toxin Toxin
PTC87_RS02755 (PTC87_02755) 590942..591244 + 303 WP_033144548.1 BrnA antitoxin family protein Antitoxin
PTC87_RS02760 (PTC87_02760) 591275..591913 - 639 WP_033144549.1 LysE family translocator -
PTC87_RS02765 (PTC87_02765) 591961..592704 - 744 WP_033146481.1 AraC family transcriptional regulator -
PTC87_RS02770 (PTC87_02770) 592856..594226 + 1371 WP_033144550.1 NAD-dependent succinate-semialdehyde dehydrogenase -
PTC87_RS02775 (PTC87_02775) 594273..594593 - 321 WP_033144551.1 hypothetical protein -
PTC87_RS02780 (PTC87_02780) 594593..595138 - 546 WP_023310269.1 YfaZ family outer membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(32-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11174.64 Da        Isoelectric Point: 6.7609

>T272161 WP_010427219.1 NZ_CP117723:590668-590955 [Enterobacter asburiae]
MPTEFEWDTNKAKSNLIKHGIRFEEAVLVFDDPYHLSLQDRHENGEFRWQTIGLVHGLIVIMVAHTVRFESGDEVIRIIS
ARKADRKERSRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11395.04 Da        Isoelectric Point: 10.2483

>AT272161 WP_033144548.1 NZ_CP117723:590942-591244 [Enterobacter asburiae]
MSMVKHKRGSAPEMSARREAELKALAEKSEAEIDYSDIPATGDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0G892

Antitoxin

Source ID Structure
AlphaFold DB A0A411GC49

References