Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 529552..530236 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag PTC87_RS02480 Protein ID WP_137397155.1
Coordinates 529895..530236 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag PTC87_RS02475 Protein ID WP_137397156.1
Coordinates 529552..529869 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS02435 (PTC87_02435) 525219..526040 + 822 WP_273922651.1 DUF932 domain-containing protein -
PTC87_RS02440 (PTC87_02440) 526259..526960 + 702 WP_273922653.1 WYL domain-containing protein -
PTC87_RS02445 (PTC87_02445) 527001..527237 + 237 WP_042015432.1 protein YpjK -
PTC87_RS02450 (PTC87_02450) 527237..527680 + 444 WP_137397160.1 hypothetical protein -
PTC87_RS02455 (PTC87_02455) 527704..528171 + 468 WP_273922657.1 protein YfjT -
PTC87_RS02460 (PTC87_02460) 528248..528487 + 240 WP_137397159.1 DUF905 domain-containing protein -
PTC87_RS02465 (PTC87_02465) 528584..529033 + 450 WP_137397158.1 antirestriction protein -
PTC87_RS02470 (PTC87_02470) 529041..529523 + 483 WP_137397157.1 DNA repair protein RadC -
PTC87_RS02475 (PTC87_02475) 529552..529869 + 318 WP_137397156.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PTC87_RS02480 (PTC87_02480) 529895..530236 + 342 WP_137397155.1 TA system toxin CbtA family protein Toxin
PTC87_RS02485 (PTC87_02485) 531004..531900 + 897 Protein_481 class I SAM-dependent DNA methyltransferase -
PTC87_RS02490 (PTC87_02490) 531972..533092 + 1121 WP_085950818.1 IS3-like element ISSen4 family transposase -
PTC87_RS02495 (PTC87_02495) 533121..534245 + 1125 Protein_483 N-6 DNA methylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 522514..542329 19815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12872.90 Da        Isoelectric Point: 8.0800

>T272160 WP_137397155.1 NZ_CP117723:529895-530236 [Enterobacter asburiae]
MKTLPAITQRAAKPCPPPVVVWQTLLARLLDQHYGLTLNDTPFSDEIVIQEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARHATGLLRHSRNNMAI

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12155.77 Da        Isoelectric Point: 6.7437

>AT272160 WP_137397156.1 NZ_CP117723:529552-529869 [Enterobacter asburiae]
VNEMTWGLQRDVTPRFGARLVQESNRLHYLSDRASITGKFSDVECLRLDEAFPHFVRQMELMLPTGELNPRHTHCVTLYH
NGFTCEADTLGSHGYVYIVIYPTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References