Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 471180..471696 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name relE Uniprot ID A0A7W2VUY1
Locus tag PTC87_RS02210 Protein ID WP_033144499.1
Coordinates 471412..471696 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag PTC87_RS02205 Protein ID WP_008501400.1
Coordinates 471180..471422 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS02190 (PTC87_02190) 467181..467921 + 741 WP_033144496.1 KDGP aldolase family protein -
PTC87_RS02195 (PTC87_02195) 468036..469172 + 1137 WP_033144497.1 lactonase family protein -
PTC87_RS02200 (PTC87_02200) 469192..471102 + 1911 WP_033144498.1 PRD domain-containing protein -
PTC87_RS02205 (PTC87_02205) 471180..471422 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PTC87_RS02210 (PTC87_02210) 471412..471696 + 285 WP_033144499.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC87_RS02215 (PTC87_02215) 471700..472164 - 465 WP_033144500.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTC87_RS02220 (PTC87_02220) 472306..474444 - 2139 WP_032662478.1 anaerobic ribonucleoside-triphosphate reductase -
PTC87_RS02225 (PTC87_02225) 474821..476464 - 1644 WP_033144501.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.3350

>T272159 WP_033144499.1 NZ_CP117723:471412-471696 [Enterobacter asburiae]
MTYELAFDPRALKEWSKLGQTVKDQFKKKLADVLVSPRVESARLHGLPDCYKIKLRSQGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT272159 WP_008501400.1 NZ_CP117723:471180-471422 [Enterobacter asburiae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2VUY1

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References