Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 350754..351280 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PTC87_RS01610 Protein ID WP_000323025.1
Coordinates 350754..351041 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag PTC87_RS01615 Protein ID WP_000534858.1
Coordinates 351041..351280 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS01590 (PTC87_01590) 345956..347914 - 1959 WP_033144420.1 acetate--CoA ligase -
PTC87_RS01595 (PTC87_01595) 348338..349651 + 1314 WP_023310067.1 glutamate/aspartate:proton symporter GltP -
PTC87_RS01600 (PTC87_01600) 349735..350409 - 675 WP_033144421.1 tetratricopeptide repeat protein -
PTC87_RS01605 (PTC87_01605) 350531..350683 - 153 WP_032644722.1 Hok/Gef family protein -
PTC87_RS01610 (PTC87_01610) 350754..351041 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PTC87_RS01615 (PTC87_01615) 351041..351280 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PTC87_RS01620 (PTC87_01620) 351305..351610 + 306 WP_001326990.1 protein YdfV -
PTC87_RS01625 (PTC87_01625) 351813..352145 + 333 WP_001317460.1 FlxA-like family protein -
PTC87_RS01630 (PTC87_01630) 352582..353922 - 1341 WP_004196353.1 IS1202-like element ISEsa1 family transposase -
PTC87_RS01635 (PTC87_01635) 354200..355135 - 936 WP_016538183.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T272158 WP_000323025.1 NZ_CP117723:c351041-350754 [Enterobacter asburiae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT272158 WP_000534858.1 NZ_CP117723:c351280-351041 [Enterobacter asburiae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References