Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 256847..257439 Replicon chromosome
Accession NZ_CP117723
Organism Enterobacter asburiae strain 2022CK-00757

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag PTC87_RS01150 Protein ID WP_033144376.1
Coordinates 257137..257439 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A808IFF3
Locus tag PTC87_RS01145 Protein ID WP_033144375.1
Coordinates 256847..257134 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTC87_RS01140 (PTC87_01140) 255219..256850 + 1632 WP_033144374.1 Na/Pi cotransporter family protein -
PTC87_RS01145 (PTC87_01145) 256847..257134 - 288 WP_033144375.1 putative addiction module antidote protein Antitoxin
PTC87_RS01150 (PTC87_01150) 257137..257439 - 303 WP_033144376.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTC87_RS01155 (PTC87_01155) 257637..258509 + 873 WP_033144377.1 23S rRNA pseudouridine(2604) synthase RluF -
PTC87_RS01160 (PTC87_01160) 258510..258782 - 273 WP_023309994.1 DUF3811 domain-containing protein -
PTC87_RS01165 (PTC87_01165) 258833..259777 - 945 WP_033144378.1 ketopantoate/pantoate/pantothenate transporter PanS -
PTC87_RS01170 (PTC87_01170) 259871..261220 - 1350 WP_033144379.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11284.02 Da        Isoelectric Point: 9.9325

>T272157 WP_033144376.1 NZ_CP117723:c257439-257137 [Enterobacter asburiae]
MKEIVQTESFQRWEQNLKDRRAKTIIASRLFRLANGLAGDIKPVGEGISELRIHYGPGYRIYFKDQGNCIIVLLCGGDKS
SQARDILMAKMLSNPNGRSE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10111.59 Da        Isoelectric Point: 6.4596

>AT272157 WP_033144375.1 NZ_CP117723:c257134-256847 [Enterobacter asburiae]
MHKLTPYDPANALVDDEEIAVFMADALETGDSAYIAKALGVIARAKGMSTISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGLGLTIKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A808IFF3

References