Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1361218..1361843 Replicon chromosome
Accession NZ_CP117720
Organism Escherichia coli strain B1W1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTA75_RS06660 Protein ID WP_000911330.1
Coordinates 1361445..1361843 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PTA75_RS06655 Protein ID WP_000450524.1
Coordinates 1361218..1361445 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA75_RS06630 (1357021) 1357021..1357491 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PTA75_RS06635 (1357491) 1357491..1358063 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PTA75_RS06640 (1358209) 1358209..1359087 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PTA75_RS06645 (1359104) 1359104..1360138 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PTA75_RS06650 (1360351) 1360351..1361064 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PTA75_RS06655 (1361218) 1361218..1361445 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PTA75_RS06660 (1361445) 1361445..1361843 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PTA75_RS06665 (1361990) 1361990..1362853 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PTA75_RS06670 (1362868) 1362868..1364883 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PTA75_RS06675 (1364957) 1364957..1365655 + 699 WP_000679823.1 esterase -
PTA75_RS06680 (1365765) 1365765..1365965 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T272138 WP_000911330.1 NZ_CP117720:1361445-1361843 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT272138 WP_000450524.1 NZ_CP117720:1361218-1361445 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References