Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 919465..920119 Replicon chromosome
Accession NZ_CP117720
Organism Escherichia coli strain B1W1

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PTA75_RS04545 Protein ID WP_000244777.1
Coordinates 919712..920119 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PTA75_RS04540 Protein ID WP_000354046.1
Coordinates 919465..919731 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA75_RS04515 (914753) 914753..915496 + 744 Protein_886 SDR family oxidoreductase -
PTA75_RS04520 (915553) 915553..916986 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PTA75_RS04525 (917031) 917031..917342 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
PTA75_RS04530 (917506) 917506..918165 + 660 WP_000250274.1 hemolysin III family protein -
PTA75_RS04535 (918242) 918242..919222 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PTA75_RS04540 (919465) 919465..919731 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PTA75_RS04545 (919712) 919712..920119 + 408 WP_000244777.1 protein YgfX Toxin
PTA75_RS04550 (920159) 920159..920680 - 522 WP_001055874.1 flavodoxin FldB -
PTA75_RS04555 (920792) 920792..921688 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PTA75_RS04560 (921713) 921713..922423 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTA75_RS04565 (922429) 922429..924162 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T272135 WP_000244777.1 NZ_CP117720:919712-920119 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272135 WP_000354046.1 NZ_CP117720:919465-919731 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References