Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 293434..294020 Replicon chromosome
Accession NZ_CP117720
Organism Escherichia coli strain B1W1

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PTA75_RS01330 Protein ID WP_042014162.1
Coordinates 293434..293664 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PTA75_RS01335 Protein ID WP_000593555.1
Coordinates 293661..294020 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA75_RS01320 (289471) 289471..292206 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
PTA75_RS01325 (292206) 292206..293330 + 1125 WP_001314210.1 ABC transporter permease -
PTA75_RS01330 (293434) 293434..293664 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PTA75_RS01335 (293661) 293661..294020 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PTA75_RS01340 (294140) 294140..294541 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PTA75_RS01345 (294547) 294547..295353 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PTA75_RS01350 (295350) 295350..296114 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PTA75_RS01355 (296114) 296114..296947 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PTA75_RS01360 (296944) 296944..297888 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T272130 WP_042014162.1 NZ_CP117720:293434-293664 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT272130 WP_000593555.1 NZ_CP117720:293661-294020 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References