Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4460614..4461111 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PTA69_RS21840 Protein ID WP_001173343.1
Coordinates 4460614..4460787 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PTA69_RS21845 Protein ID WP_000398619.1
Coordinates 4460815..4461111 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS21830 (4457284) 4457284..4458741 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
PTA69_RS21835 (4458978) 4458978..4460495 + 1518 WP_001295087.1 lysine--tRNA ligase -
PTA69_RS21840 (4460614) 4460614..4460787 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PTA69_RS21845 (4460815) 4460815..4461111 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PTA69_RS21850 (4461338) 4461338..4461610 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
PTA69_RS21855 (4461622) 4461622..4461852 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PTA69_RS21860 (4462033) 4462033..4463664 + 1632 WP_001216487.1 sensor histidine kinase -
PTA69_RS21865 (4463661) 4463661..4464380 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T272120 WP_001173343.1 NZ_CP117717:c4460787-4460614 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT272120 WP_000398619.1 NZ_CP117717:c4461111-4460815 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References