272118

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3672717..3673554 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PTA69_RS18015 Protein ID WP_000227784.1
Coordinates 3673012..3673554 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PTA69_RS18010 Protein ID WP_001297137.1
Coordinates 3672717..3673028 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS17985 (3667737) 3667737..3668684 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
PTA69_RS17990 (3668706) 3668706..3670697 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PTA69_RS17995 (3670687) 3670687..3671301 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PTA69_RS18000 (3671301) 3671301..3671630 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PTA69_RS18005 (3671642) 3671642..3672532 + 891 WP_000971336.1 heme o synthase -
PTA69_RS18010 (3672717) 3672717..3673028 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PTA69_RS18015 (3673012) 3673012..3673554 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PTA69_RS18020 (3673610) 3673610..3674545 - 936 WP_001368479.1 tetratricopeptide repeat protein -
PTA69_RS18025 (3674953) 3674953..3676317 + 1365 WP_001000960.1 MFS transporter -
PTA69_RS18030 (3676445) 3676445..3676936 - 492 WP_001138904.1 nucleotide binding protein YajQ -
PTA69_RS18035 (3677104) 3677104..3678015 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T272118 WP_000227784.1 NZ_CP117717:3673012-3673554 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT272118 WP_001297137.1 NZ_CP117717:3672717-3673028 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References