Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3638640..3639258 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag PTA69_RS17845 Protein ID WP_062874123.1
Coordinates 3639040..3639258 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PTA69_RS17840 Protein ID WP_000344800.1
Coordinates 3638640..3639014 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS17830 (3633729) 3633729..3634922 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PTA69_RS17835 (3634945) 3634945..3638094 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PTA69_RS17840 (3638640) 3638640..3639014 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PTA69_RS17845 (3639040) 3639040..3639258 + 219 WP_062874123.1 HHA domain-containing protein Toxin
PTA69_RS17850 (3639430) 3639430..3639981 + 552 WP_000102564.1 maltose O-acetyltransferase -
PTA69_RS17855 (3640097) 3640097..3640567 + 471 WP_000136192.1 YlaC family protein -
PTA69_RS17860 (3640731) 3640731..3642281 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PTA69_RS17865 (3642323) 3642323..3642676 - 354 WP_000878141.1 DUF1428 family protein -
PTA69_RS17875 (3643055) 3643055..3643366 + 312 WP_000409911.1 MGMT family protein -
PTA69_RS17880 (3643397) 3643397..3643969 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8704.10 Da        Isoelectric Point: 8.8580

>T272117 WP_062874123.1 NZ_CP117717:3639040-3639258 [Escherichia coli]
MYEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272117 WP_000344800.1 NZ_CP117717:3638640-3639014 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References