Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2454349..2455445 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name hipA Uniprot ID A0A8S7TJ53
Locus tag PTA69_RS12050 Protein ID WP_063112742.1
Coordinates 2454615..2455445 (+) Length 277 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PTA69_RS12045 Protein ID WP_001296726.1
Coordinates 2454349..2454615 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS12045 (2454349) 2454349..2454615 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PTA69_RS12050 (2454615) 2454615..2455445 + 831 WP_063112742.1 HipA N-terminal domain-containing protein Toxin
PTA69_RS12055 (2455757) 2455757..2455965 + 209 Protein_2360 AraC family transcriptional regulator -
PTA69_RS12060 (2456397) 2456397..2456960 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
PTA69_RS12065 (2457320) 2457320..2458030 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2454349..2471282 16933


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(115-237)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 277 a.a.        Molecular weight: 31181.99 Da        Isoelectric Point: 10.0235

>T272116 WP_063112742.1 NZ_CP117717:2454615-2455445 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEKLTEARLEDRYDFMKFQVFQWLIGATDGHAKNFSVFIQAGGS
YRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIPAALD
NVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 831 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT272116 WP_001296726.1 NZ_CP117717:2454349-2454615 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References