Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1359238..1359863 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTA69_RS06565 Protein ID WP_000911330.1
Coordinates 1359465..1359863 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PTA69_RS06560 Protein ID WP_000450524.1
Coordinates 1359238..1359465 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS06535 (1355041) 1355041..1355511 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PTA69_RS06540 (1355511) 1355511..1356083 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PTA69_RS06545 (1356229) 1356229..1357107 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PTA69_RS06550 (1357124) 1357124..1358158 + 1035 WP_001330579.1 outer membrane protein assembly factor BamC -
PTA69_RS06555 (1358371) 1358371..1359084 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PTA69_RS06560 (1359238) 1359238..1359465 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PTA69_RS06565 (1359465) 1359465..1359863 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PTA69_RS06570 (1360010) 1360010..1360873 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PTA69_RS06575 (1360888) 1360888..1362903 + 2016 WP_063112794.1 tRNA cytosine(34) acetyltransferase TmcA -
PTA69_RS06580 (1362977) 1362977..1363675 + 699 WP_000679823.1 esterase -
PTA69_RS06585 (1363785) 1363785..1363985 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T272110 WP_000911330.1 NZ_CP117717:1359465-1359863 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT272110 WP_000450524.1 NZ_CP117717:1359238-1359465 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References