Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 913405..914059 Replicon chromosome
Accession NZ_CP117717
Organism Escherichia coli strain B1S11

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag PTA69_RS04445 Protein ID WP_063112724.1
Coordinates 913652..914059 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PTA69_RS04440 Protein ID WP_000354046.1
Coordinates 913405..913671 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA69_RS04415 (908693) 908693..909436 + 744 WP_000951964.1 SDR family oxidoreductase -
PTA69_RS04420 (909493) 909493..910926 - 1434 WP_001307385.1 6-phospho-beta-glucosidase BglA -
PTA69_RS04425 (910971) 910971..911282 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
PTA69_RS04430 (911446) 911446..912105 + 660 WP_000250274.1 hemolysin III family protein -
PTA69_RS04435 (912182) 912182..913162 - 981 WP_001472148.1 tRNA-modifying protein YgfZ -
PTA69_RS04440 (913405) 913405..913671 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PTA69_RS04445 (913652) 913652..914059 + 408 WP_063112724.1 protein YgfX Toxin
PTA69_RS04450 (914099) 914099..914620 - 522 WP_001055874.1 flavodoxin FldB -
PTA69_RS04455 (914732) 914732..915628 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PTA69_RS04460 (915653) 915653..916363 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTA69_RS04465 (916369) 916369..918102 + 1734 WP_000813210.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16082.04 Da        Isoelectric Point: 11.2511

>T272108 WP_063112724.1 NZ_CP117717:913652-914059 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLFHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT272108 WP_000354046.1 NZ_CP117717:913405-913671 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References