Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4364951..4365448 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PTA50_RS21165 Protein ID WP_001173343.1
Coordinates 4364951..4365124 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PTA50_RS21170 Protein ID WP_000398619.1
Coordinates 4365152..4365448 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS21155 (4361621) 4361621..4363078 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
PTA50_RS21160 (4363315) 4363315..4364832 + 1518 WP_001295074.1 lysine--tRNA ligase -
PTA50_RS21165 (4364951) 4364951..4365124 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PTA50_RS21170 (4365152) 4365152..4365448 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PTA50_RS21175 (4365675) 4365675..4365947 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PTA50_RS21180 (4365959) 4365959..4366189 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PTA50_RS21185 (4366370) 4366370..4368001 + 1632 WP_001216486.1 sensor histidine kinase -
PTA50_RS21190 (4367998) 4367998..4368717 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T272095 WP_001173343.1 NZ_CP117714:c4365124-4364951 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT272095 WP_000398619.1 NZ_CP117714:c4365448-4365152 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References