Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4268455..4269050 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PTA50_RS20665 Protein ID WP_000239579.1
Coordinates 4268455..4268805 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A4D0VVQ9
Locus tag PTA50_RS20670 Protein ID WP_001223207.1
Coordinates 4268799..4269050 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS20645 (4263731) 4263731..4264753 - 1023 WP_001296689.1 ABC transporter permease -
PTA50_RS20650 (4264767) 4264767..4266269 - 1503 WP_000205795.1 sugar ABC transporter ATP-binding protein -
PTA50_RS20655 (4266579) 4266579..4267535 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PTA50_RS20660 (4267845) 4267845..4268375 + 531 WP_000055072.1 inorganic diphosphatase -
PTA50_RS20665 (4268455) 4268455..4268805 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PTA50_RS20670 (4268799) 4268799..4269050 - 252 WP_001223207.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PTA50_RS20675 (4269263) 4269263..4269604 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PTA50_RS20680 (4269607) 4269607..4273386 - 3780 WP_000060927.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T272094 WP_000239579.1 NZ_CP117714:c4268805-4268455 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9285.61 Da        Isoelectric Point: 4.4201

>AT272094 WP_001223207.1 NZ_CP117714:c4269050-4268799 [Escherichia coli]
MRITIKRWGNSAGMVIPNILMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A4D0VVQ9

References