Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3522565..3523183 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PTA50_RS17070 Protein ID WP_001291435.1
Coordinates 3522965..3523183 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PTA50_RS17065 Protein ID WP_000344800.1
Coordinates 3522565..3522939 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS17055 (3517654) 3517654..3518847 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PTA50_RS17060 (3518870) 3518870..3522019 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PTA50_RS17065 (3522565) 3522565..3522939 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PTA50_RS17070 (3522965) 3522965..3523183 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PTA50_RS17075 (3523354) 3523354..3523905 + 552 WP_000102578.1 maltose O-acetyltransferase -
PTA50_RS17080 (3524021) 3524021..3524491 + 471 WP_000136192.1 YlaC family protein -
PTA50_RS17085 (3524655) 3524655..3526205 + 1551 WP_001365886.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PTA50_RS17090 (3526247) 3526247..3526600 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PTA50_RS17100 (3526979) 3526979..3527290 + 312 WP_000409911.1 MGMT family protein -
PTA50_RS17105 (3527321) 3527321..3527893 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T272090 WP_001291435.1 NZ_CP117714:3522965-3523183 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT272090 WP_000344800.1 NZ_CP117714:3522565-3522939 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References