Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1348450..1349075 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PTA50_RS06555 Protein ID WP_000911329.1
Coordinates 1348677..1349075 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PTA50_RS06550 Protein ID WP_000450524.1
Coordinates 1348450..1348677 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS06525 (1344252) 1344252..1344722 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PTA50_RS06530 (1344722) 1344722..1345294 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PTA50_RS06535 (1345440) 1345440..1346318 + 879 WP_001311023.1 4-hydroxy-tetrahydrodipicolinate synthase -
PTA50_RS06540 (1346335) 1346335..1347369 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PTA50_RS06545 (1347582) 1347582..1348295 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PTA50_RS06550 (1348450) 1348450..1348677 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PTA50_RS06555 (1348677) 1348677..1349075 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PTA50_RS06560 (1349222) 1349222..1350085 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PTA50_RS06565 (1350100) 1350100..1352115 + 2016 WP_000829294.1 tRNA cytosine(34) acetyltransferase TmcA -
PTA50_RS06570 (1352189) 1352189..1352887 + 699 WP_000679823.1 esterase -
PTA50_RS06575 (1352997) 1352997..1353197 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T272083 WP_000911329.1 NZ_CP117714:1348677-1349075 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT272083 WP_000450524.1 NZ_CP117714:1348450-1348677 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References