Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 783912..784710 | Replicon | chromosome |
| Accession | NZ_CP117714 | ||
| Organism | Escherichia coli strain PBS4 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | PTA50_RS03815 | Protein ID | WP_072665353.1 |
| Coordinates | 783912..784286 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A3W5RLB4 |
| Locus tag | PTA50_RS03820 | Protein ID | WP_041124172.1 |
| Coordinates | 784333..784710 (-) | Length | 126 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PTA50_RS03780 (779061) | 779061..779624 | + | 564 | WP_001115140.1 | type II secretion system minor pseudopilin GspH | - |
| PTA50_RS03785 (779621) | 779621..779992 | + | 372 | WP_000820125.1 | type II secretion system minor pseudopilin GspI | - |
| PTA50_RS03790 (779989) | 779989..780588 | + | 600 | WP_001255040.1 | type II secretion system minor pseudopilin GspJ | - |
| PTA50_RS03795 (780591) | 780591..781568 | + | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| PTA50_RS03800 (781565) | 781565..782743 | + | 1179 | WP_000094971.1 | type II secretion system protein GspL | - |
| PTA50_RS03805 (782745) | 782745..783281 | + | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| PTA50_RS03810 (783562) | 783562..783900 | - | 339 | WP_227456471.1 | DUF5983 family protein | - |
| PTA50_RS03815 (783912) | 783912..784286 | - | 375 | WP_072665353.1 | TA system toxin CbtA family protein | Toxin |
| PTA50_RS03820 (784333) | 784333..784710 | - | 378 | WP_041124172.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
| PTA50_RS03825 (784786) | 784786..785007 | - | 222 | WP_000692307.1 | DUF987 domain-containing protein | - |
| PTA50_RS03830 (785076) | 785076..785552 | - | 477 | WP_021559500.1 | RadC family protein | - |
| PTA50_RS03835 (785568) | 785568..786053 | - | 486 | WP_041124170.1 | antirestriction protein | - |
| PTA50_RS03840 (786145) | 786145..786963 | - | 819 | WP_001234621.1 | DUF932 domain-containing protein | - |
| PTA50_RS03845 (787062) | 787062..787295 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| PTA50_RS03850 (787301) | 787301..787978 | - | 678 | WP_021559490.1 | hypothetical protein | - |
| PTA50_RS03855 (788129) | 788129..788809 | - | 681 | WP_001282912.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | papC / papD | 783912..832794 | 48882 | |
| - | inside | Genomic island | - | - | 783912..810033 | 26121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14063.00 Da Isoelectric Point: 7.2920
>T272080 WP_072665353.1 NZ_CP117714:c784286-783912 [Escherichia coli]
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
MNTLPDTHVRETSGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR
Download Length: 375 bp
>T272080 NZ_CP117714:c784286-783912 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
ATGAATACATTACCCGACACTCACGTACGGGAGACATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA
Antitoxin
Download Length: 126 a.a. Molecular weight: 13752.57 Da Isoelectric Point: 6.2021
>AT272080 WP_041124172.1 NZ_CP117714:c784710-784333 [Escherichia coli]
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
VSDTLPGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRASIRGRFSDADAYHLDQAFPLLMKQLELMLTGG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAAPAITV
Download Length: 378 bp
>AT272080 NZ_CP117714:c784710-784333 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGTCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCAGTATCAGAGGCAGGT
TCAGCGACGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCGGCGGT
GAACTGAATCCCCGTCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAATCACCGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|