Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 269053..269639 Replicon chromosome
Accession NZ_CP117714
Organism Escherichia coli strain PBS4

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PTA50_RS01225 Protein ID WP_042014162.1
Coordinates 269053..269283 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PTA50_RS01230 Protein ID WP_000593555.1
Coordinates 269280..269639 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTA50_RS01215 (265090) 265090..267825 + 2736 WP_000149168.1 ribosome-associated ATPase/putative transporter RbbA -
PTA50_RS01220 (267825) 267825..268949 + 1125 WP_001314210.1 ABC transporter permease -
PTA50_RS01225 (269053) 269053..269283 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PTA50_RS01230 (269280) 269280..269639 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PTA50_RS01235 (269759) 269759..270160 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PTA50_RS01240 (270166) 270166..270972 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PTA50_RS01245 (270969) 270969..271733 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PTA50_RS01250 (271733) 271733..272566 - 834 WP_001008968.1 nickel ABC transporter permease subunit NikC -
PTA50_RS01255 (272563) 272563..273507 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T272077 WP_042014162.1 NZ_CP117714:269053-269283 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT272077 WP_000593555.1 NZ_CP117714:269280-269639 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References