Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4185454..4186235 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag PRJ38_RS20285 Protein ID WP_023255089.1
Coordinates 4185454..4185945 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PRJ38_RS20290 Protein ID WP_001271379.1
Coordinates 4185942..4186235 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS20260 (4182335) 4182335..4183165 - 831 WP_079948288.1 fimbria/pilus periplasmic chaperone -
PRJ38_RS20265 (4183367) 4183367..4183672 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PRJ38_RS20270 (4184204) 4184204..4184347 + 144 Protein_3969 transposase -
PRJ38_RS20275 (4184364) 4184364..4184710 + 347 Protein_3970 Rpn family recombination-promoting nuclease/putative transposase -
PRJ38_RS20280 (4184991) 4184991..4185239 - 249 Protein_3971 IS481 family transposase -
PRJ38_RS20285 (4185454) 4185454..4185945 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
PRJ38_RS20290 (4185942) 4185942..4186235 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PRJ38_RS20295 (4186553) 4186553..4186775 + 223 Protein_3974 hypothetical protein -
PRJ38_RS20300 (4187041) 4187041..4187916 + 876 WP_000921674.1 AraC family transcriptional regulator -
PRJ38_RS20305 (4187913) 4187913..4188200 + 288 WP_001269916.1 transcriptional regulator RtsB -
PRJ38_RS20310 (4188223) 4188223..4188437 + 215 Protein_3977 hypothetical protein -
PRJ38_RS20315 (4188445) 4188445..4188588 + 144 Protein_3978 hypothetical protein -
PRJ38_RS20320 (4188700) 4188700..4188789 + 90 Protein_3979 hypothetical protein -
PRJ38_RS20325 (4189078) 4189078..4189983 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4174847..4189938 15091


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T272071 WP_023255089.1 NZ_CP117698:c4185945-4185454 [Salmonella enterica subsp. enterica serovar London]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT272071 WP_001271379.1 NZ_CP117698:c4186235-4185942 [Salmonella enterica subsp. enterica serovar London]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References