Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4071105..4071621 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag PRJ38_RS19660 Protein ID WP_000220581.1
Coordinates 4071105..4071389 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PRJ38_RS19665 Protein ID WP_000212724.1
Coordinates 4071379..4071621 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS19645 (4066317) 4066317..4067969 + 1653 WP_023257400.1 alpha,alpha-phosphotrehalase -
PRJ38_RS19650 (4068378) 4068378..4070516 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PRJ38_RS19655 (4070637) 4070637..4071101 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PRJ38_RS19660 (4071105) 4071105..4071389 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PRJ38_RS19665 (4071379) 4071379..4071621 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PRJ38_RS19670 (4071699) 4071699..4073612 - 1914 WP_001212148.1 BglG family transcription antiterminator -
PRJ38_RS19675 (4073629) 4073629..4074369 - 741 WP_023229489.1 KDGP aldolase family protein -
PRJ38_RS19680 (4074366) 4074366..4075484 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PRJ38_RS19685 (4075468) 4075468..4076601 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T272070 WP_000220581.1 NZ_CP117698:c4071389-4071105 [Salmonella enterica subsp. enterica serovar London]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT272070 WP_000212724.1 NZ_CP117698:c4071621-4071379 [Salmonella enterica subsp. enterica serovar London]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References