Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3381767..3382387 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PRJ38_RS16490 Protein ID WP_001280991.1
Coordinates 3382169..3382387 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PRJ38_RS16485 Protein ID WP_000344807.1
Coordinates 3381767..3382141 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS16475 (3376906) 3376906..3378099 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PRJ38_RS16480 (3378122) 3378122..3381271 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PRJ38_RS16485 (3381767) 3381767..3382141 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PRJ38_RS16490 (3382169) 3382169..3382387 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PRJ38_RS16495 (3382566) 3382566..3383117 + 552 WP_023243161.1 maltose O-acetyltransferase -
PRJ38_RS16500 (3383235) 3383235..3383705 + 471 WP_000136183.1 YlaC family protein -
PRJ38_RS16505 (3383761) 3383761..3383901 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PRJ38_RS16510 (3383907) 3383907..3384167 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PRJ38_RS16515 (3384392) 3384392..3385942 + 1551 WP_000213145.1 EAL domain-containing protein -
PRJ38_RS16525 (3386173) 3386173..3386562 + 390 WP_000961285.1 MGMT family protein -
PRJ38_RS16530 (3386595) 3386595..3387164 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272066 WP_001280991.1 NZ_CP117698:3382169-3382387 [Salmonella enterica subsp. enterica serovar London]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272066 WP_000344807.1 NZ_CP117698:3381767-3382141 [Salmonella enterica subsp. enterica serovar London]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References