Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 852828..853453 Replicon chromosome
Accession NZ_CP117698
Organism Salmonella enterica subsp. enterica serovar London strain L1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PRJ38_RS04125 Protein ID WP_000911337.1
Coordinates 853055..853453 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PRJ38_RS04120 Protein ID WP_000557549.1
Coordinates 852828..853055 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PRJ38_RS04090 (847893) 847893..848991 + 1099 WP_010989230.1 peptide chain release factor 2 -
PRJ38_RS04095 (849001) 849001..850518 + 1518 WP_000003339.1 lysine--tRNA ligase -
PRJ38_RS04100 (850594) 850594..851139 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PRJ38_RS04105 (851404) 851404..852162 + 759 WP_000244328.1 amidase activator ActS -
PRJ38_RS04115 (852408) 852408..852605 - 198 WP_023255488.1 hypothetical protein -
PRJ38_RS04120 (852828) 852828..853055 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PRJ38_RS04125 (853055) 853055..853453 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PRJ38_RS04130 (854259) 854259..854795 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PRJ38_RS04135 (854842) 854842..855474 + 633 WP_000835264.1 YfdX family protein -
PRJ38_RS04140 (856193) 856193..856777 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 852828..862645 9817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T272060 WP_000911337.1 NZ_CP117698:853055-853453 [Salmonella enterica subsp. enterica serovar London]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT272060 WP_000557549.1 NZ_CP117698:852828-853055 [Salmonella enterica subsp. enterica serovar London]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References