Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4186610..4187391 Replicon chromosome
Accession NZ_CP117696
Organism Salmonella enterica subsp. enterica serovar London strain F1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag PTQ22_RS20290 Protein ID WP_023255089.1
Coordinates 4186610..4187101 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PTQ22_RS20295 Protein ID WP_001271379.1
Coordinates 4187098..4187391 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ22_RS20265 (4183491) 4183491..4184321 - 831 WP_079948288.1 fimbria/pilus periplasmic chaperone -
PTQ22_RS20270 (4184523) 4184523..4184828 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PTQ22_RS20275 (4185360) 4185360..4185503 + 144 Protein_3970 transposase -
PTQ22_RS20280 (4185520) 4185520..4185866 + 347 Protein_3971 Rpn family recombination-promoting nuclease/putative transposase -
PTQ22_RS20285 (4186147) 4186147..4186395 - 249 Protein_3972 IS481 family transposase -
PTQ22_RS20290 (4186610) 4186610..4187101 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
PTQ22_RS20295 (4187098) 4187098..4187391 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PTQ22_RS20300 (4187709) 4187709..4187931 + 223 Protein_3975 hypothetical protein -
PTQ22_RS20305 (4188197) 4188197..4189072 + 876 WP_000921674.1 AraC family transcriptional regulator -
PTQ22_RS20310 (4189069) 4189069..4189356 + 288 WP_001269916.1 transcriptional regulator RtsB -
PTQ22_RS20315 (4189379) 4189379..4189593 + 215 Protein_3978 hypothetical protein -
PTQ22_RS20320 (4189601) 4189601..4189744 + 144 Protein_3979 hypothetical protein -
PTQ22_RS20325 (4189856) 4189856..4189945 + 90 Protein_3980 hypothetical protein -
PTQ22_RS20330 (4190234) 4190234..4191139 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4176003..4189945 13942
- inside Genomic island - - 4176003..4189356 13353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T272054 WP_023255089.1 NZ_CP117696:c4187101-4186610 [Salmonella enterica subsp. enterica serovar London]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT272054 WP_001271379.1 NZ_CP117696:c4187391-4187098 [Salmonella enterica subsp. enterica serovar London]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References