Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986880..3987456 Replicon chromosome
Accession NZ_CP117696
Organism Salmonella enterica subsp. enterica serovar London strain F1

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PTQ22_RS19275 Protein ID WP_001131963.1
Coordinates 3987169..3987456 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5J0SGD3
Locus tag PTQ22_RS19270 Protein ID WP_023254955.1
Coordinates 3986880..3987182 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ22_RS19255 (3983390) 3983390..3985540 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
PTQ22_RS19260 (3985635) 3985635..3985838 + 204 WP_000460616.1 YbdD/YjiX family protein -
PTQ22_RS19265 (3985849) 3985849..3986805 + 957 WP_000187838.1 GTPase -
PTQ22_RS19270 (3986880) 3986880..3987182 - 303 WP_023254955.1 BrnA antitoxin family protein Antitoxin
PTQ22_RS19275 (3987169) 3987169..3987456 - 288 WP_001131963.1 BrnT family toxin Toxin
PTQ22_RS19280 (3987725) 3987725..3988639 - 915 WP_000290515.1 restriction endonuclease -
PTQ22_RS19285 (3988837) 3988837..3992346 + 3510 WP_023256869.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T272052 WP_001131963.1 NZ_CP117696:c3987456-3987169 [Salmonella enterica subsp. enterica serovar London]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11346.01 Da        Isoelectric Point: 10.1339

>AT272052 WP_023254955.1 NZ_CP117696:c3987182-3986880 [Salmonella enterica subsp. enterica serovar London]
MSMVKHKRGNACALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSGAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5J0SGD3

References