Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 853894..854519 Replicon chromosome
Accession NZ_CP117696
Organism Salmonella enterica subsp. enterica serovar London strain F1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PTQ22_RS04135 Protein ID WP_000911337.1
Coordinates 854121..854519 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag PTQ22_RS04130 Protein ID WP_000557549.1
Coordinates 853894..854121 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ22_RS04100 (848959) 848959..850057 + 1099 WP_010989230.1 peptide chain release factor 2 -
PTQ22_RS04105 (850067) 850067..851584 + 1518 WP_000003339.1 lysine--tRNA ligase -
PTQ22_RS04110 (851660) 851660..852205 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
PTQ22_RS04115 (852470) 852470..853228 + 759 WP_000244328.1 amidase activator ActS -
PTQ22_RS04125 (853474) 853474..853671 - 198 WP_023255488.1 hypothetical protein -
PTQ22_RS04130 (853894) 853894..854121 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
PTQ22_RS04135 (854121) 854121..854519 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
PTQ22_RS04140 (855325) 855325..855861 + 537 WP_001038500.1 STM3031 family outer membrane protein -
PTQ22_RS04145 (855908) 855908..856540 + 633 WP_000835264.1 YfdX family protein -
PTQ22_RS04150 (857259) 857259..857843 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 853894..863711 9817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T272043 WP_000911337.1 NZ_CP117696:854121-854519 [Salmonella enterica subsp. enterica serovar London]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT272043 WP_000557549.1 NZ_CP117696:853894-854121 [Salmonella enterica subsp. enterica serovar London]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References