Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 844135..844795 Replicon chromosome
Accession NZ_CP117696
Organism Salmonella enterica subsp. enterica serovar London strain F1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I0Q7R2
Locus tag PTQ22_RS04075 Protein ID WP_023255487.1
Coordinates 844382..844795 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3U5J6N8
Locus tag PTQ22_RS04070 Protein ID WP_058805755.1
Coordinates 844135..844401 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ22_RS04050 (840064) 840064..841497 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PTQ22_RS04055 (841655) 841655..841966 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PTQ22_RS04060 (842130) 842130..842789 + 660 WP_000250289.1 hemolysin III family protein -
PTQ22_RS04065 (842905) 842905..843885 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PTQ22_RS04070 (844135) 844135..844401 + 267 WP_058805755.1 FAD assembly factor SdhE Antitoxin
PTQ22_RS04075 (844382) 844382..844795 + 414 WP_023255487.1 protein YgfX Toxin
PTQ22_RS04080 (844848) 844848..845369 - 522 WP_001055885.1 flavodoxin FldB -
PTQ22_RS04085 (845482) 845482..846378 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PTQ22_RS04090 (846402) 846402..847115 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTQ22_RS04095 (847121) 847121..848854 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T272042 WP_023255487.1 NZ_CP117696:844382-844795 [Salmonella enterica subsp. enterica serovar London]
VILWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10608.09 Da        Isoelectric Point: 5.5844

>AT272042 WP_058805755.1 NZ_CP117696:844135-844401 [Salmonella enterica subsp. enterica serovar London]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERDPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I0Q7R2

Antitoxin

Source ID Structure
AlphaFold DB A0A3U5J6N8

References