Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4294468..4295249 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag PTQ18_RS20880 Protein ID WP_023255089.1
Coordinates 4294468..4294959 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag PTQ18_RS20885 Protein ID WP_001271379.1
Coordinates 4294956..4295249 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS20855 (4291349) 4291349..4292179 - 831 WP_079948288.1 fimbria/pilus periplasmic chaperone -
PTQ18_RS20860 (4292381) 4292381..4292686 - 306 WP_000370555.1 PapB/FocB family fimbrial expression transcriptional regulator -
PTQ18_RS20865 (4293218) 4293218..4293361 + 144 Protein_4086 transposase -
PTQ18_RS20870 (4293378) 4293378..4293724 + 347 Protein_4087 Rpn family recombination-promoting nuclease/putative transposase -
PTQ18_RS20875 (4294005) 4294005..4294253 - 249 Protein_4088 IS481 family transposase -
PTQ18_RS20880 (4294468) 4294468..4294959 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
PTQ18_RS20885 (4294956) 4294956..4295249 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
PTQ18_RS20890 (4295567) 4295567..4295789 + 223 Protein_4091 hypothetical protein -
PTQ18_RS20895 (4296055) 4296055..4296930 + 876 WP_000921674.1 AraC family transcriptional regulator -
PTQ18_RS20900 (4296927) 4296927..4297214 + 288 WP_001269916.1 transcriptional regulator RtsB -
PTQ18_RS20905 (4297237) 4297237..4297451 + 215 Protein_4094 hypothetical protein -
PTQ18_RS20910 (4297459) 4297459..4297602 + 144 Protein_4095 hypothetical protein -
PTQ18_RS20915 (4297714) 4297714..4297803 + 90 Protein_4096 hypothetical protein -
PTQ18_RS20920 (4298092) 4298092..4298997 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4283861..4297803 13942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T272037 WP_023255089.1 NZ_CP117693:c4294959-4294468 [Salmonella enterica subsp. enterica serovar London]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT272037 WP_001271379.1 NZ_CP117693:c4295249-4294956 [Salmonella enterica subsp. enterica serovar London]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References