Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4179887..4180403 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag PTQ18_RS20250 Protein ID WP_000220581.1
Coordinates 4179887..4180171 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag PTQ18_RS20255 Protein ID WP_000212724.1
Coordinates 4180161..4180403 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS20235 (4175099) 4175099..4176751 + 1653 WP_023257400.1 alpha,alpha-phosphotrehalase -
PTQ18_RS20240 (4177160) 4177160..4179298 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
PTQ18_RS20245 (4179419) 4179419..4179883 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
PTQ18_RS20250 (4179887) 4179887..4180171 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PTQ18_RS20255 (4180161) 4180161..4180403 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PTQ18_RS20260 (4180481) 4180481..4182394 - 1914 WP_001212148.1 BglG family transcription antiterminator -
PTQ18_RS20265 (4182411) 4182411..4183151 - 741 WP_023229489.1 KDGP aldolase family protein -
PTQ18_RS20270 (4183148) 4183148..4184266 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
PTQ18_RS20275 (4184250) 4184250..4185383 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T272036 WP_000220581.1 NZ_CP117693:c4180171-4179887 [Salmonella enterica subsp. enterica serovar London]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT272036 WP_000212724.1 NZ_CP117693:c4180403-4180161 [Salmonella enterica subsp. enterica serovar London]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References