Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 3986242..3986818 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag PTQ18_RS19275 Protein ID WP_001131963.1
Coordinates 3986531..3986818 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5J0SGD3
Locus tag PTQ18_RS19270 Protein ID WP_023254955.1
Coordinates 3986242..3986544 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS19255 (3982752) 3982752..3984902 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
PTQ18_RS19260 (3984997) 3984997..3985200 + 204 WP_000460616.1 YbdD/YjiX family protein -
PTQ18_RS19265 (3985211) 3985211..3986167 + 957 WP_000187838.1 GTPase -
PTQ18_RS19270 (3986242) 3986242..3986544 - 303 WP_023254955.1 BrnA antitoxin family protein Antitoxin
PTQ18_RS19275 (3986531) 3986531..3986818 - 288 WP_001131963.1 BrnT family toxin Toxin
PTQ18_RS19280 (3987087) 3987087..3988001 - 915 WP_000290515.1 restriction endonuclease -
PTQ18_RS19285 (3988199) 3988199..3991708 + 3510 WP_023256869.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T272035 WP_001131963.1 NZ_CP117693:c3986818-3986531 [Salmonella enterica subsp. enterica serovar London]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11346.01 Da        Isoelectric Point: 10.1339

>AT272035 WP_023254955.1 NZ_CP117693:c3986544-3986242 [Salmonella enterica subsp. enterica serovar London]
MSMVKHKRGNACALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSGAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5J0SGD3

References