Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3382053..3382673 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PTQ18_RS16490 Protein ID WP_001280991.1
Coordinates 3382455..3382673 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag PTQ18_RS16485 Protein ID WP_000344807.1
Coordinates 3382053..3382427 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS16475 (3377192) 3377192..3378385 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PTQ18_RS16480 (3378408) 3378408..3381557 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
PTQ18_RS16485 (3382053) 3382053..3382427 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
PTQ18_RS16490 (3382455) 3382455..3382673 + 219 WP_001280991.1 HHA domain-containing protein Toxin
PTQ18_RS16495 (3382852) 3382852..3383403 + 552 WP_023243161.1 maltose O-acetyltransferase -
PTQ18_RS16500 (3383521) 3383521..3383991 + 471 WP_000136183.1 YlaC family protein -
PTQ18_RS16505 (3384047) 3384047..3384187 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
PTQ18_RS16510 (3384193) 3384193..3384453 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
PTQ18_RS16515 (3384678) 3384678..3386228 + 1551 WP_000213145.1 EAL domain-containing protein -
PTQ18_RS16525 (3386459) 3386459..3386848 + 390 WP_000961285.1 MGMT family protein -
PTQ18_RS16530 (3386881) 3386881..3387450 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272032 WP_001280991.1 NZ_CP117693:3382455-3382673 [Salmonella enterica subsp. enterica serovar London]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT272032 WP_000344807.1 NZ_CP117693:3382053-3382427 [Salmonella enterica subsp. enterica serovar London]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References