Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843069..843729 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I0Q7R2
Locus tag PTQ18_RS04065 Protein ID WP_023255487.1
Coordinates 843316..843729 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3U5J6N8
Locus tag PTQ18_RS04060 Protein ID WP_058805755.1
Coordinates 843069..843335 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS04040 (838998) 838998..840431 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
PTQ18_RS04045 (840589) 840589..840900 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
PTQ18_RS04050 (841064) 841064..841723 + 660 WP_000250289.1 hemolysin III family protein -
PTQ18_RS04055 (841839) 841839..842819 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
PTQ18_RS04060 (843069) 843069..843335 + 267 WP_058805755.1 FAD assembly factor SdhE Antitoxin
PTQ18_RS04065 (843316) 843316..843729 + 414 WP_023255487.1 protein YgfX Toxin
PTQ18_RS04070 (843782) 843782..844303 - 522 WP_001055885.1 flavodoxin FldB -
PTQ18_RS04075 (844416) 844416..845312 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
PTQ18_RS04080 (845336) 845336..846049 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PTQ18_RS04085 (846055) 846055..847788 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T272025 WP_023255487.1 NZ_CP117693:843316-843729 [Salmonella enterica subsp. enterica serovar London]
VILWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10608.09 Da        Isoelectric Point: 5.5844

>AT272025 WP_058805755.1 NZ_CP117693:843069-843335 [Salmonella enterica subsp. enterica serovar London]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERDPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I0Q7R2

Antitoxin

Source ID Structure
AlphaFold DB A0A3U5J6N8

References