Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 219592..220352 Replicon chromosome
Accession NZ_CP117693
Organism Salmonella enterica subsp. enterica serovar London strain S1

Toxin (Protein)


Gene name tacT Uniprot ID A0A5J1SP54
Locus tag PTQ18_RS01030 Protein ID WP_023256507.1
Coordinates 219867..220352 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag PTQ18_RS01025 Protein ID WP_000965886.1
Coordinates 219592..219879 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PTQ18_RS01005 (214997) 214997..215908 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
PTQ18_RS01010 (215918) 215918..217987 + 2070 WP_023255847.1 glycine--tRNA ligase subunit beta -
PTQ18_RS01015 (218377) 218377..218775 + 399 Protein_201 IS3 family transposase -
PTQ18_RS01020 (218947) 218947..219414 + 468 WP_023256506.1 GNAT family N-acetyltransferase -
PTQ18_RS01025 (219592) 219592..219879 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
PTQ18_RS01030 (219867) 219867..220352 + 486 WP_023256507.1 GNAT family N-acetyltransferase Toxin
PTQ18_RS01035 (220723) 220723..221262 - 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
PTQ18_RS01040 (221436) 221436..221648 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
PTQ18_RS01045 (221936) 221936..222226 - 291 WP_000455790.1 HTH-type transcriptional regulator -
PTQ18_RS01050 (222665) 222665..223375 + 711 WP_000190524.1 DUF3053 domain-containing protein -
PTQ18_RS01055 (223425) 223425..224399 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
PTQ18_RS01060 (224618) 224618..225280 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(52-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17749.42 Da        Isoelectric Point: 9.7701

>T272023 WP_023256507.1 NZ_CP117693:219867-220352 [Salmonella enterica subsp. enterica serovar London]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVYKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVELSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQQTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT272023 WP_000965886.1 NZ_CP117693:219592-219879 [Salmonella enterica subsp. enterica serovar London]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1SP54

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References