272020

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/Xre(antitoxin)
Location 5335..5833 Replicon plasmid pEA4_36
Accession NZ_CP117682
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name TsxA Uniprot ID A0A7L6LHZ8
Locus tag PS033_RS25000 Protein ID WP_000868277.1
Coordinates 5335..5601 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID A0A3H7VMJ5
Locus tag PS033_RS25005 Protein ID WP_001450803.1
Coordinates 5591..5833 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS24980 (PS033_24980) 697..1710 - 1014 WP_024176825.1 replication initiation protein -
PS033_RS24985 (PS033_24985) 4376..4699 + 324 WP_000432877.1 hypothetical protein -
PS033_RS24990 (PS033_24990) 4740..4964 + 225 WP_000866040.1 hypothetical protein -
PS033_RS24995 (PS033_24995) 5060..5284 + 225 WP_000749828.1 hypothetical protein -
PS033_RS25000 (PS033_25000) 5335..5601 + 267 WP_000868277.1 hypothetical protein Toxin
PS033_RS25005 (PS033_25005) 5591..5833 + 243 WP_001450803.1 hypothetical protein Antitoxin
PS033_RS25010 (PS033_25010) 6273..6602 + 330 WP_000387851.1 hypothetical protein -
PS033_RS25015 (PS033_25015) 6660..6938 + 279 WP_000545934.1 hypothetical protein -
PS033_RS25020 (PS033_25020) 7369..7551 + 183 WP_000833471.1 type II toxin-antitoxin system HicA family toxin -
PS033_RS25025 (PS033_25025) 7576..8013 + 438 WP_000466317.1 type II toxin-antitoxin system HicB family antitoxin -
PS033_RS25030 (PS033_25030) 8042..8746 - 705 WP_080171974.1 hypothetical protein -
PS033_RS25035 (PS033_25035) 8743..9504 - 762 WP_075319719.1 conjugal transfer protein TraL -
PS033_RS25040 (PS033_25040) 9522..9923 - 402 WP_181503405.1 zinc transporter -
PS033_RS25045 (PS033_25045) 10292..10627 + 336 WP_000963832.1 DUF6290 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..36239 36239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10205.74 Da        Isoelectric Point: 10.4299

>T272020 WP_000868277.1 NZ_CP117682:5335-5601 [Escherichia albertii]
MKVRKGDRQYYLNKEGNMFHLVKRVKTFSKSATLGKTKATVKTVADLVFNEKAFDTIDFSRDGLRENDKEIVSMMIQEMN
NERGKNVN

Download         Length: 267 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9288.69 Da        Isoelectric Point: 9.7120

>AT272020 WP_001450803.1 NZ_CP117682:5591-5833 [Escherichia albertii]
MLTENTPENIKRLRQKIGLTQRECAEIFSMNPRTWRRKEEPAGTASGTALTPVEFKYLQLLAGEHPEYVLRKRDKPKCSE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6LHZ8

Antitoxin

Source ID Structure
AlphaFold DB A0A3H7VMJ5

References