Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 62032..62675 Replicon plasmid pEA4_88
Accession NZ_CP117680
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag PS033_RS24435 Protein ID WP_042093420.1
Coordinates 62259..62675 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag PS033_RS24430 Protein ID WP_059268686.1
Coordinates 62032..62262 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS24400 (57632) 57632..57979 - 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -
PS033_RS24405 (57979) 57979..58626 - 648 WP_059268691.1 IS66-like element accessory protein TnpA -
PS033_RS24410 (58907) 58907..59662 - 756 WP_000807692.1 replication initiation protein RepE -
PS033_RS24415 (60071) 60071..60877 - 807 WP_059268688.1 site-specific integrase -
PS033_RS24420 (60878) 60878..61183 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
PS033_RS24425 (61185) 61185..61403 - 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA -
PS033_RS24430 (62032) 62032..62262 + 231 WP_059268686.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PS033_RS24435 (62259) 62259..62675 + 417 WP_042093420.1 PIN domain-containing protein Toxin
PS033_RS24440 (62845) 62845..64983 - 2139 WP_059268683.1 AAA family ATPase -
PS033_RS24445 (65548) 65548..66504 - 957 WP_187646074.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..88280 88280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.41 Da        Isoelectric Point: 7.2450

>T272017 WP_042093420.1 NZ_CP117680:62259-62675 [Escherichia albertii]
VNKTYMLDTNICSFIMREQPEAVIRRLEQAVLRNHRIVVSAITYAEMRFGAIGKKASPRHGQLVDAFCARLDAILPWDRA
AVDATVEVKAALTAAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.93 Da        Isoelectric Point: 4.8011

>AT272017 WP_059268686.1 NZ_CP117680:62032-62262 [Escherichia albertii]
MRTVSIFKNGNNRAIRLPRDLDFEGVSKLEIIREGDSIILRPVRPTWSSFAQLEKADTDFLVEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References