Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-Phd
Location 68638..69239 Replicon plasmid pEA4_97
Accession NZ_CP117679
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name doc Uniprot ID V0AJ64
Locus tag PS033_RS23870 Protein ID WP_001216034.1
Coordinates 68638..69018 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID U9YQH9
Locus tag PS033_RS23875 Protein ID WP_001190712.1
Coordinates 69018..69239 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS23845 (PS033_23845) 64079..65563 - 1485 WP_273780393.1 terminase -
PS033_RS23850 (PS033_23850) 65563..66756 - 1194 WP_273780395.1 terminase -
PS033_RS23855 (PS033_23855) 66842..67294 - 453 WP_001326849.1 late promoter-activating protein -
PS033_RS23860 (PS033_23860) 67383..68426 - 1044 WP_047655059.1 DUF968 domain-containing protein -
PS033_RS23865 (PS033_23865) 68454..68633 - 180 WP_059268434.1 hypothetical protein -
PS033_RS23870 (PS033_23870) 68638..69018 - 381 WP_001216034.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
PS033_RS23875 (PS033_23875) 69018..69239 - 222 WP_001190712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PS033_RS23880 (PS033_23880) 69422..70977 + 1556 Protein_74 type I restriction-modification system subunit M -
PS033_RS23885 (PS033_23885) 70974..72167 + 1194 WP_059268435.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..97069 97069
- flank IS/Tn - - 62775..63962 1187


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-123)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-51)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13615.32 Da        Isoelectric Point: 5.1514

>T272014 WP_001216034.1 NZ_CP117679:c69018-68638 [Escherichia albertii]
MRHISPEELIALHDANINRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE

Download         Length: 381 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8133.10 Da        Isoelectric Point: 4.7708

>AT272014 WP_001190712.1 NZ_CP117679:c69239-69018 [Escherichia albertii]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0AJ64

Antitoxin

Source ID Structure
AlphaFold DB A0A829CJB6

References