Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4209634..4210252 Replicon chromosome
Accession NZ_CP117678
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag PS033_RS20605 Protein ID WP_001280991.1
Coordinates 4209634..4209852 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B1EKM5
Locus tag PS033_RS20610 Protein ID WP_000344798.1
Coordinates 4209878..4210252 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS20570 (4204916) 4204916..4205488 + 573 WP_059267833.1 YbaY family lipoprotein -
PS033_RS20575 (4205518) 4205518..4205829 - 312 WP_000409915.1 MGMT family protein -
PS033_RS20585 (4206210) 4206210..4206563 + 354 WP_000878151.1 DUF1428 family protein -
PS033_RS20590 (4206601) 4206601..4208151 - 1551 WP_001260378.1 EAL domain-containing protein -
PS033_RS20595 (4208315) 4208315..4208785 - 471 WP_000136188.1 YlaC family protein -
PS033_RS20600 (4208893) 4208893..4209450 - 558 WP_059221620.1 maltose O-acetyltransferase -
PS033_RS20605 (4209634) 4209634..4209852 - 219 WP_001280991.1 HHA domain-containing protein Toxin
PS033_RS20610 (4209878) 4209878..4210252 - 375 WP_000344798.1 Hha toxicity modulator TomB Antitoxin
PS033_RS20615 (4210807) 4210807..4213956 - 3150 WP_059267834.1 efflux RND transporter permease AcrB -
PS033_RS20620 (4213979) 4213979..4215172 - 1194 WP_010334435.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T272013 WP_001280991.1 NZ_CP117678:c4209852-4209634 [Escherichia albertii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14499.35 Da        Isoelectric Point: 4.8989

>AT272013 WP_000344798.1 NZ_CP117678:c4210252-4209878 [Escherichia albertii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKANPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3RX90

References