Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2733993..2734793 Replicon chromosome
Accession NZ_CP117678
Organism Escherichia albertii strain BIA_4

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag PS033_RS13730 Protein ID WP_059220924.1
Coordinates 2733993..2734520 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID B1EHP0
Locus tag PS033_RS13735 Protein ID WP_001277106.1
Coordinates 2734527..2734793 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PS033_RS13705 (2729068) 2729068..2729835 - 768 WP_273778032.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PS033_RS13710 (2729832) 2729832..2731109 - 1278 WP_273778035.1 branched chain amino acid ABC transporter permease LivM -
PS033_RS13715 (2731106) 2731106..2732032 - 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PS033_RS13720 (2732080) 2732080..2733189 - 1110 WP_059267945.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PS033_RS13725 (2733613) 2733613..2733996 + 384 WP_059267944.1 aspartate 1-decarboxylase autocleavage activator PanM -
PS033_RS13730 (2733993) 2733993..2734520 - 528 WP_059220924.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PS033_RS13735 (2734527) 2734527..2734793 - 267 WP_001277106.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PS033_RS13740 (2734943) 2734943..2736046 - 1104 WP_010319184.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PS033_RS13745 (2736318) 2736318..2737172 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PS033_RS13750 (2737417) 2737417..2738475 - 1059 WP_001042000.1 permease-like cell division protein FtsX -
PS033_RS13755 (2738468) 2738468..2739136 - 669 WP_000617720.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19490.38 Da        Isoelectric Point: 6.6303

>T272010 WP_059220924.1 NZ_CP117678:c2734520-2733993 [Escherichia albertii]
MDDLTIEILTDDADYDLQRLDCGEEALNLFLTTHLVRQHRNKILRAYILCSNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVCSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9942.37 Da        Isoelectric Point: 10.0863

>AT272010 WP_001277106.1 NZ_CP117678:c2734793-2734527 [Escherichia albertii]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z8E004

References