Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 44496..45121 Replicon plasmid pKW21
Accession NZ_CP117673
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PSR34_RS23930 Protein ID WP_000911313.1
Coordinates 44496..44894 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PSR34_RS23935 Protein ID WP_000450520.1
Coordinates 44894..45121 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS23915 (40821) 40821..41318 + 498 WP_000605857.1 entry exclusion protein -
PSR34_RS23920 (41350) 41350..42081 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
PSR34_RS23925 (42334) 42334..44487 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
PSR34_RS23930 (44496) 44496..44894 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
PSR34_RS23935 (44894) 44894..45121 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / aac(3)-IId / aph(3')-Ia / mph(A) / oqxA / oqxB / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / blaCTX-M-55 / fosA3 / dfrA14 / dfrA12 / aadA2 / sitABCD iucA / iucB / iucC / iucD / iutA / iroN / iroE / iroD / iroC / iroB 1..179817 179817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T271999 WP_000911313.1 NZ_CP117673:c44894-44496 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT271999 WP_000450520.1 NZ_CP117673:c45121-44894 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References