Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4378039..4378536 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PSR34_RS21460 Protein ID WP_001173343.1
Coordinates 4378039..4378212 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PSR34_RS21465 Protein ID WP_000398619.1
Coordinates 4378240..4378536 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS21450 (4374709) 4374709..4376166 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
PSR34_RS21455 (4376403) 4376403..4377920 + 1518 WP_023155344.1 lysine--tRNA ligase -
PSR34_RS21460 (4378039) 4378039..4378212 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PSR34_RS21465 (4378240) 4378240..4378536 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PSR34_RS21470 (4378763) 4378763..4379035 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PSR34_RS21475 (4379047) 4379047..4379277 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
PSR34_RS21480 (4379458) 4379458..4381089 + 1632 WP_001216460.1 sensor histidine kinase -
PSR34_RS21485 (4381086) 4381086..4381805 + 720 WP_000611287.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T271994 WP_001173343.1 NZ_CP117672:c4378212-4378039 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT271994 WP_000398619.1 NZ_CP117672:c4378536-4378240 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References