Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4282105..4282700 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PSR34_RS20965 Protein ID WP_000239579.1
Coordinates 4282105..4282455 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PSR34_RS20970 Protein ID WP_001223208.1
Coordinates 4282449..4282700 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS20945 (4277551) 4277551..4278573 - 1023 WP_001296689.1 ABC transporter permease -
PSR34_RS20950 (4278587) 4278587..4280089 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
PSR34_RS20955 (4280229) 4280229..4281185 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PSR34_RS20960 (4281495) 4281495..4282025 + 531 WP_000055072.1 inorganic diphosphatase -
PSR34_RS20965 (4282105) 4282105..4282455 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PSR34_RS20970 (4282449) 4282449..4282700 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PSR34_RS20975 (4282913) 4282913..4283254 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PSR34_RS20980 (4283257) 4283257..4287036 - 3780 WP_001402801.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T271993 WP_000239579.1 NZ_CP117672:c4282455-4282105 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT271993 WP_001223208.1 NZ_CP117672:c4282700-4282449 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References