Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3549369..3549987 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PSR34_RS17335 Protein ID WP_001291435.1
Coordinates 3549769..3549987 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PSR34_RS17330 Protein ID WP_000344800.1
Coordinates 3549369..3549743 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS17320 (3544897) 3544897..3548046 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PSR34_RS17325 (3548297) 3548297..3548994 + 698 WP_223216367.1 IS1 family transposase -
PSR34_RS17330 (3549369) 3549369..3549743 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PSR34_RS17335 (3549769) 3549769..3549987 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PSR34_RS17340 (3550159) 3550159..3550710 + 552 WP_040091271.1 maltose O-acetyltransferase -
PSR34_RS17345 (3550826) 3550826..3551296 + 471 WP_000136192.1 YlaC family protein -
PSR34_RS17350 (3551460) 3551460..3553010 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PSR34_RS17355 (3553052) 3553052..3553405 - 354 WP_000878141.1 DUF1428 family protein -
PSR34_RS17365 (3553784) 3553784..3554095 + 312 WP_000409911.1 MGMT family protein -
PSR34_RS17370 (3554126) 3554126..3554698 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T271991 WP_001291435.1 NZ_CP117672:3549769-3549987 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT271991 WP_000344800.1 NZ_CP117672:3549369-3549743 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References