Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1324069..1324694 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PSR34_RS06380 Protein ID WP_000911330.1
Coordinates 1324296..1324694 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PSR34_RS06375 Protein ID WP_000450524.1
Coordinates 1324069..1324296 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS06350 (1319871) 1319871..1320341 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PSR34_RS06355 (1320341) 1320341..1320913 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PSR34_RS06360 (1321059) 1321059..1321937 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PSR34_RS06365 (1321954) 1321954..1322988 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PSR34_RS06370 (1323201) 1323201..1323914 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PSR34_RS06375 (1324069) 1324069..1324296 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PSR34_RS06380 (1324296) 1324296..1324694 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PSR34_RS06385 (1324841) 1324841..1325704 + 864 WP_001267507.1 neutral zinc metallopeptidase -
PSR34_RS06390 (1325719) 1325719..1327734 + 2016 WP_032283657.1 tRNA cytosine(34) acetyltransferase TmcA -
PSR34_RS06395 (1327808) 1327808..1328506 + 699 WP_000679823.1 esterase -
PSR34_RS06400 (1328616) 1328616..1328816 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T271984 WP_000911330.1 NZ_CP117672:1324296-1324694 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT271984 WP_000450524.1 NZ_CP117672:1324069-1324296 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References