Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856140..856794 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PSR34_RS04220 Protein ID WP_000244781.1
Coordinates 856387..856794 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PSR34_RS04215 Protein ID WP_000354046.1
Coordinates 856140..856406 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS04190 (851309) 851309..852052 + 744 WP_000951961.1 SDR family oxidoreductase -
PSR34_RS04195 (852109) 852109..853542 - 1434 WP_032283547.1 6-phospho-beta-glucosidase BglA -
PSR34_RS04200 (853587) 853587..853898 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PSR34_RS04205 (854062) 854062..854721 + 660 WP_000250274.1 hemolysin III family protein -
PSR34_RS04210 (854917) 854917..855897 - 981 WP_000886095.1 tRNA-modifying protein YgfZ -
PSR34_RS04215 (856140) 856140..856406 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PSR34_RS04220 (856387) 856387..856794 + 408 WP_000244781.1 protein YgfX Toxin
PSR34_RS04225 (856834) 856834..857355 - 522 WP_001055874.1 flavodoxin FldB -
PSR34_RS04230 (857467) 857467..858363 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PSR34_RS04235 (858388) 858388..859098 + 711 WP_000715208.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PSR34_RS04240 (859104) 859104..860837 + 1734 WP_000813223.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T271982 WP_000244781.1 NZ_CP117672:856387-856794 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT271982 WP_000354046.1 NZ_CP117672:856140-856406 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References