Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 254231..254817 Replicon chromosome
Accession NZ_CP117672
Organism Escherichia coli strain KW21

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PSR34_RS01155 Protein ID WP_042014162.1
Coordinates 254231..254461 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PSR34_RS01160 Protein ID WP_000593555.1
Coordinates 254458..254817 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSR34_RS01145 (250268) 250268..253003 + 2736 WP_040091132.1 ribosome-associated ATPase/putative transporter RbbA -
PSR34_RS01150 (253003) 253003..254127 + 1125 WP_001216257.1 ABC transporter permease -
PSR34_RS01155 (254231) 254231..254461 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PSR34_RS01160 (254458) 254458..254817 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSR34_RS01165 (254937) 254937..255338 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PSR34_RS01170 (255344) 255344..256150 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PSR34_RS01175 (256147) 256147..256911 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PSR34_RS01180 (256911) 256911..257744 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PSR34_RS01185 (257741) 257741..258685 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T271979 WP_042014162.1 NZ_CP117672:254231-254461 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT271979 WP_000593555.1 NZ_CP117672:254458-254817 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References